Jujuboside A 55466-04-1
Jujuboside A
CAS: 55466-04-1
Molecular Formula: C58H94O26
Jujuboside A 55466-04-1 - Names and Identifiers
| Name | Jujuboside A |
| Synonyms | JUJUBOSIDE A Jujuboside A Jujuboside A 55466-04-1 Ziziphus jujuba Mill. Var glucopyranosyl-(1→6)-O-[β-D-xylopyranosyl-(1→2)]-β-D-glucopyranosyl-(1→3)]- -diepoxy-20-hydroxydammar-24-en-3-ylO-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[O-β-D- |
| CAS | 55466-04-1 |
| InChI | InChI=1/C58H94O26/c1-23(2)15-25-16-56(8,72)47-26-9-10-32-54(6)13-12-33(53(4,5)31(54)11-14-55(32,7)57(26)21-58(47,84-25)76-22-57)80-51-46(83-50-43(71)38(66)34(62)24(3)77-50)44(28(61)19-74-51)81-52-45(82-49-41(69)35(63)27(60)18-73-49)40(68)37(65)30(79-52)20-75-48-42(70)39(67)36(64)29(17-59)78-48/h15,24-52,59-72H,9-14,16-22H2,1-8H3/t24-,25-,26+,27+,28-,29+,30+,31-,32+,33-,34-,35-,36+,37+,38+,39-,40-,41+,42+,43+,44-,45+,46+,47-,48+,49-,50-,51?,52-,54-,55+,56-,57?,58-/m0/s1 |
Jujuboside A 55466-04-1 - Physico-chemical Properties
| Molecular Formula | C58H94O26 |
| Molar Mass | 1207.35 |
| Density | 1.50 |
| Melting Point | 222-225°C |
| Specific Rotation(α) | -50.1 (c, 0.43 in MeOH) |
| Solubility | Easily soluble in methanol, almost insoluble in ether |
| Appearance | White powder |
| pKa | 12.81±0.70(Predicted) |
| Storage Condition | 2-8°C |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.639 |
| MDL | MFCD03427709 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, almost insoluble in ether, derived from semen ziziphi spinosae. |
Jujuboside A 55466-04-1 - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29389090 |
Jujuboside A 55466-04-1 - Reference
| Reference Show more | 1. Zhu Hongyan, Zhang, na, Tang, Shan, et al. Determination of sinopinoside and ziziphi spinosae saponin A B in semen ziziphi spinosae from three different regions by HPLC [J]. Journal of Pharmaceutical Analysis, 2015 035(012):2099-2104. 2. Hongyan, Linhai, Chengyang, heguoli, Zhao Yan, Changyu steel, Zhang Lianxue. Optimization of extraction process of total saponins from semen ziziphi spinosae by Central composite design-response surface methodology [J]. Journal of Food Safety and quality testing 2014 5(11):3718-3726. 3. Peng Meng, Zhang, Hui, Hui, doucong, et al. Study on the metabolic transformation of human fecal incubation solution on semen ziziphi spinosae saponin A [J]. Liaoning Journal of Traditional Chinese Medicine, 2016 043(007):1459-1462. 4. Lin Haicheng, Zhu Hongyan, He Zhongmei, etc. Optimization of extraction technology of total saponins from semen ziziphi spinosae by orthogonal test [J]. Chinese Journal of Experimental prescriptions, 2015, 21(5):42-45. 5. Wen zishuai, Li Xinrui, Mu Panpan, etc. Study on the content determination and quality grade classification standard of semen ziziphi spinosae and semen ziziphi spinosae saponin A in semen ziziphi spinosae. 6. Wei Lin, Li Bolin, Jiang Xiaojuan, etc. Effects of semen ziziphi spinosae saponin A on adenosine release and nucleoside transporters in prefrontal cortex of mice [J]. Journal of Changchun University of Traditional Chinese Medicine, 2018, 34(005):836-838, front insert 1. 7. Zhu Hongyan, Zhang Na, Wang Guoli, Jiang ran, he Zhongmei, Zhang Lianxue. Simultaneous determination of ginsenoside Rg_1, Re, Rb_1 and jujuboside A, B in renshen jianpi pills by HPLC [J]. Chinese Pharmaceutical Journal, 2016,51(09):751-756. 8. Jiao Yang, Ding Jingxin, Xiangming Sun, et al. Optimization of extraction technology of Jiawei suanzaoren decoction granules by orthogonal test [J]. Journal of Harbin University of Commerce (natural sciences edition), 2017, 33(002):138-144. 9. Liao Mei, Xu Yao, Lan Jinshan. Simultaneous determination of wild jujube seed saponin A, wild jujube seed saponin B and spinoxin in Lily jujube seed bag tea by HPLC-MS method [J]. China modern distance education of traditional Chinese medicine, 2021,19(03):143-146. 10. Wen Baoqing, Li Wenqing, Zhou Miaoxia, Lin kunxia, Wang Xiaodong, Qian Zhengming. Identification and analysis of chemical constituents in fushenyin by core-shell chromatography-quadrupole time-of-flight mass spectrometry [J]. Shi Zhen, National Medicine, 2020,31(06):1334-1338. 11. [IF = 2.431] Sun Yan et al. Saponins extracted by ultrasound from Zizyphus Juju Mil var. spinosa leaves exon resistance. "J Food Meas Charact. 2021 Feb;15(1):541-554 12. [IF=2.408] Fang-Tong Li et al."In Vitro Effects of Ginseng and the Seed of Zizyphus jujuba var. spinosa on Gut Microbiota of Rats with Spleen Deficiency."Chem Biodivers. 2020 Sep;17(9):e2000199 |
Jujuboside A 55466-04-1 - Reference Information
| Introduction | semen ziziphi spinosae saponin A is an index component contained in the Chinese Pharmacopoeia (2015 Edition). Ziziphi Spinosae (Ziziphi Spinosae) is a plant of the genus Ziziphus (Ziziphus jujubaMill). var.spinosa(Bunge)Huex H.F. The dried and mature seeds of Chu), alias jujube kernel, jujube nucleus, sweet taste, flat sex, with liver, Ning heart, sweating, the role of fluid, for the virtual trouble sleep, fear and dream, body weakness, sweating, the "Compendium of Materia Medica" lists it as the top grade. |
| effect | ziziphin A is A neuroprotective agent extracted from semen ziziphi spinosae, and is used as A hypnotic sedative compound. Semen ziziphi spinosae has high medicinal value, and its pharmacological effects have been deeply studied. Semen ziziphi spinosae saponin is a high content component in semen ziziphi spinosae, which has a wide range of biological activities, such as sedation and hypnosis, anti-myocardial ischemia, anti-depression, hypolipidemic and antihypertensive. |
| preparation | A method for preparing A high-purity semen ziziphi spinosae saponin A reference: A. Raw material extraction: the semen ziziphi spinosae is added to 5-8 times the amount of ethanol solution according to the volume mass ratio L/Kg, and the volume percentage concentration of the used ethanol solution is 60-75%; the semen ziziphi spinosae and the ethanol solution are heat-extracted at least 2 times at 60 ° C. For about 2 hours each time, cooled to room temperature, suction filtered, and the filtrates are combined and concentrated to have no alcoholic taste; B. Macroporous resin enrichment: the concentrated solution of Step A is statically adsorbed with macroporous resin overnight, and then impurities are eluted with 2-3 times the volume of column water and 2-5 times the volume of Column 15-30% ethanol solution, the target substance was eluted with 50-65% ethanol solution 1-3 times the volume of the column, and the eluate was collected and concentrated to 1/10 of the original volume; C. Extraction: adding 1-2 times the amount of n-butanol to the concentrated solution of Step B, extracting, collecting the n-butanol layer, and concentrating to obtain the alcohol extract of ziziphi spinosae saponin a described in step (I); D. Medium pressure preparation: Step C of the alcohol extract of semen ziziphi spinosae saponin A was dissolved in 50% acetonitrile water on medium pressure preparation column, Eluted with 30% acetonitrile and concentrated to obtain A semi-finished product of semen ziziphi spinosae saponin A with A purity of about 60%; E. Gel purification: about 60% of crude semen ziziphi spinosae saponin A obtained in step D was purified by dissolving in 50% methanol water on gel column, washed with 50% methanol water, and detected by HPLC, the target fraction was collected, concentrated and freeze-dried to obtain crude semen ziziphi spinosae saponin A with A purity of about 95%; F. High-pressure preparation: about 95% of crude semen ziziphi spinosae saponin A obtained in Step E was dissolved in 58% methanol water, high-pressure preparation was carried out, and 58% methanol water was washed off to collect A target fraction; G. Product recovery: the high-pressure fraction obtained in step F was concentrated and freeze-dried to obtain A reference product of ziziphi spinosae saponin A with A purity of 100%. |
| uses | semen ziziphi spinosae saponin A has sedative, hypnotic, anti-aging, anti-atherosclerosis and anti-cancer effects. for content determination/identification/pharmacological experiments. Pharmacological Efficacy: anti-arrhythmic effect. |
Last Update：2024-04-09 20:49:11
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